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Mutations in several genes have been associated with monogenic forms of Parkinson's disease, including SNCA, LRRK2, Parkin, PINK1 , and DJ-1

[Google Scholar] 275.Cilio S., Rienzo M., Villano G., Mirto B.F., Giampaglia G., Capone F., Ferretti G., Di Zazzo E., Crocetto F

Further advantages of this system include a reduced cost and size of animal studies as a consequence of efficient in vitro compound selection, lower skill requirements compared to myocardial surgery in animal work, and the possibility to incorporate iPSC cardiomyocytes

The bioenergetic status and microenvironment of the three metabolic states indicate that differences in metabolic activity are unlikely to have been influenced by differences in tissue perfusion, the presence of necrosis, differences in cell proliferation or the presence of immune cell infiltrates, but rather represent tumour-cell-intrinsic metabolic phenotypes