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In human muscle cell studies 4 , IGF-1 directly increased myotube nuclei, fusion index, and myosin heavy chain content, all key indicators of muscle growth
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Williams et al, 1997), and some researchers postulated that activated platelets could bring about this overexpression in colorectal cancers via the production of IL-1 , PGDF and TGF- (Sciulli et al, 2005)
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