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Both v6 and v8 integrins facilitate TGF activation by interacting with the RGD sequence present in the latent, inactive LAP (latency-associated peptide)-TGF complex
CagriSema Side Effects# In REDEFINE 1, GI adverse events affected 79.6% of participants in the CagriSema group vs 39.9% in the placebo group
10.1101/gad.279737.116 [DOI] [PMC free article] [PubMed] [Google Scholar] Gasparri A
Chem Rev 121:17461803
