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Christopher Shade, a leader in detoxification and functional medicine

4.3 Germline mutations in DNA methyltransferases and resulting immunopathology Three enzymesDNMT1, DNMT3A, and DNMT3Bdirectly catalyze the addition of methyl groups onto DNA

This improvement is likely an indirect effect of enhanced plant vigor and metabolic activity 25

Additional topical options demonstrate varying mechanisms: Kojic acid 1-4%: Daily application with moderate tyrosinase inhibition Vitamin C serum 10-20%: Daily application with weak to moderate tyrosinase inhibition Tranexamic acid 2-5%: Twice daily application using anti-inflammatory mechanisms Systematic reviews document superior efficacy with combination therapy using oral plus topical glutathione versus monotherapy