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Folate-mediated One-carbon Metabolism (FOCM) FOCM comprises a network of biochemical reactions that generate and transfer one-carbon units for various biosynthetic processes [1]

The conversion from homocysteine to cystathionine by cystathionine -synthase (CBS) is described to be a key player in restoring intracellular cysteine pool as decreasing its expression increases sensitivity to ferroptosis in ovarian cancer cells upon erastin treatment (56)

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