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Other considerations to take into account include systemic side effects, interactions with other disorders in which elevated BDNF levels can have harmful long-term consequences, and the potential impact of different polymorphisms on the efficacy of BDNF-based therapies

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4 Oxidative stress and AD The pathophysiology of AD is multifaceted, and impaired aortic integrity is a fundamental mechanism in the pathology of AD, which results from the inherent instability of the aortic wall (e.g., due to inherited connective tissue diseases) or acquired conditions (e.g., atherosclerotic degeneration associated with aging) (64)