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However, more detailed mechanistic studies have shown that protein nitration by peroxynitrite requires transition metals, such as ferrous iron

Although TAM can exhibit both pro-inflammatory M1-type and anti-inflammatory M2-type polarized forms, it is generally accepted that TAM exhibit similar functions to M2-type macrophages, promoting tumor growth, metastasis, angiogenesis, and immunosuppression by secreting cytokines, chemokines, and proteases (62)

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49 Cardiomyocyte-specific CITED4 expression was found to induce an increase in heart weight and cardiomyocyte size, while did not stimulate significant cardiomyocyte proliferation in the heart