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Not only is it central in the process of BBB disruption and the instigation of the inflammatory response, it also is directly affected by bioenergetic failure from hypoxia, which, among other processes, causes glutamate-induced excitotoxicity, where astrocytes play a pivotal role ( Discussion Despite decades of research on ME/CFS, there remains a fundamental haziness around its pathobiological matrix

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Institutional review boards and research oversight committees play a crucial role in ensuring experimental protocols meet scientific and regulatory standards
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