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Since we have now shown that the 1st glutathione-interaction site can serve not only as a scaffold site for GSSR substrates but also as an activator site for GSH for the reduction of non-glutathione disulfide substrates, we would like to suggest to preferably use the terms 1st and 2nd glutathione-interaction site (e.g., in combination with the function as a scaffold or activator) to avoid ambiguities in the future

However, optimizing combination regimens demands precision in dosing schedules, administration routes, and patient-specific factors to minimize off-target effects

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