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In cardiomyocytes, the intermediate GSH:GSSG ratios may cause reversible mitochondrial m, while strongly decreased ratios can cause irreversible PTP activation (Aon et al
Am J Pathol 2011;178:911923
Hennigar et al., 2017), in addition to inducing the subsequent release of other cytokines with anti-inflammatory function [interleukin-1 receptor antagonist (IL-1ra) and interleukin-10 (IL-10)] (Hotamisligil et al., 1996)
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