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The National Institute on Aging Interventions Testing Program evaluates agents hypothesized to increase healthy lifespan in genetically heterogeneous mice ( As of Cohort 11, C2017, nine agents have shown significant extension of median lifespan: acarbose, aspirin, canagliflozin, captopril, glycine, nordihydroguaiaretic acid, Protandim, rapamycin, and 17-estradiol [82,83,84,85,86,87,88,89,90]