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The FRP in the figure shows the final targets after the two screens

Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis

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Additionally, the presence of a threoninol moiety at the C-terminus necessitates the use of nonconventional SPPS strategies, particularly in the choice of resin, linker and cleavage solution