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However, these findings should be regarded as hypothesis-generating and require validation through targeted in vitro functional assays, transcriptomic analyses, and in vivo studies to establish bioavailability, efficacy, and safety under physiological conditions

Images were analyzed using a deep learning-based neural network as described elsewhere 68

For first-line drugs, isoniazid (INH) resistance is primarily associated with mutations in the katG gene, which encodes the catalase-peroxidase enzyme responsible for activating INH (Rivire et al., 2020)

Current evidence suggests that its functional outputs are markedly context-dependent