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Much of this research has been in the context of CVD-adjacent metabolic diseases
They observed no difference in this parameter between the presynaptic boutons even under high-intensity stimulation of neurotransmitter release (600AP) [58]

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In addition to this, there are various factors contributing to oxidative stress in FRDA, including mitochondrial labile iron, NRF2 expression, lipid peroxidation, and Ca 2+ homeostasis, which means therapeutics may need to combat a number of these factors to overcome oxidative stress
