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Its easy to see how thickened tissues in your joints can cause pain and immobility, but theres another problem at play, too

European surgical research Europaische chirurgische Forschung Recherches chirurgicales europeennes

Specifically, polymorphisms in the Na V 1.4 (SCN4A-rs2302237) and Na V 1.8 genes (SCN10A-rs1263292) have been associated with increased incidence of acute oxaliplatin-induced neuropathy (Argyriou et al., 2013a), while patients carrying a polymorphism (rs6746030) in the SCN9A gene encoding for Na V 1.7 seem to develop less severe neuropathy than patients carrying other SCN9A gene variants (Sereno et al., 2017)

The amount and frequency of glutathione IV infusions necessary depends on the desired outcome