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As of 29 December 2020, neonatal screening programs for SMA were available in Taiwan, USA, Germany, Belgium, Australia, Italy, Russia, Canada, and Japan [160]
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Interestingly, inhibition of NLRP3 inflammasome activation reversed the M1 polarization of TMAO-stimulated macrophages, suggesting that NLRP3 plays a crucial role as a proteolytic activator in TMAO-induced macrophage responses
