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Similarly, in HFD combined with streptozotocin (STZ) injected mice and PA-treated AML-12 cells, researchers found that Puerarin treatment was able to effectively inhibit ferroptosis and reduce lipid peroxidation by activating the SIRT1/NRF2 pathway and increasing the expression of HO-1, SLC7A11, and GPX4 proteins [145]
Clin Chem 61(3):544-53, 2015
Trivedi, M
New biotechnological tools such as RNA interference, CRISPR-Cas gene editing, and nanotechnology offer tremendous potential for disease mitigation
