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In aged mice, research has demonstrated several key changes that contribute to the development of DE, including disruption of corneal barrier function, heightened ocular surface inflammation [151], loss of meibomian glands [152], and increased levels of oxidative stress within the lacrimal glands [153, 154]
And they found that within the first week, this was for people with ulcerative colitis who were having a flare that were not responsive to traditional therapies
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