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When ACSL4 is knocked down in vitro, the survival rate and invasiveness of lung cancer cells are enhanced, on the contrary, overexpression would promote ferroptosis of lung cancer cells [95]
In addition, ASX has been demonstrated to enhance clinical outcomes and reduce mortality in animal models of pneumonia [66,67,68]
doi: 10.1016/j.molcel.2016.05.002 15 ClaudiB.SproteP.ChirkovaA.PersonnicN.ZanklJ.SchurmannN.et al
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