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Naturally Occurring Copper-Binding Tripeptide GHK-Cu is a tripeptide (glycinehistidinelysine) complexed with copper (Cu) that occurs naturally in human plasma, saliva, and urine

Finally, acute application of the mature form of BDNF on hippocampal slices facilitates the early phase of long-term potentiation (LTP [32,33,34];)

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4.2.2.2 Notoginsenoside R1 (NGR1) NGR1 is a novel saponin from Panax notoginseng, a TCM for the adjuvant treatment of DKD (210),which demonstrated that NGR1 treatment increased serum lipids in db/db mice, reduced AGE-induced mitochondrial damage, limited the increase in ROS, reduced apoptosis in HK-2 cells, promoted the expression of nuclear factor erythroid 2-related factor 2(Nrf2) and heme oxygenase-1(HO-1) to abrogate apoptosis-inducing and TGF- signaling by ROS, attenuated histological abnormalities in the kidney, reduced glomerular volume in DKD, inhibited oxidative stress-induced apoptosis and renal fibrosis, and delayed DKD (211)