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10.7554/eLife.28533 [DOI] [PMC free article] [PubMed] 69.Mashimo M, Kato J, Moss J (2014) Structure and function of the ARH family of ADP-ribosyl-acceptor hydrolases

Histologically, epidermal thickening, severe hyperkeratosis, and epidermal acanthosis were seen ( Mll4 -knockout mice developed red, scaly skin ( Alox12 , Alox12b , and AloxE3 expressions were downregulated

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Quantitative genetics, however, had already predicted in the last century, albeit in a non-specific manner, that some characteristics were influenced by the environment, so much so that today we speak of quantitative trait loci precisely to indicate these characteristics