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[22] [23] Baseline assessment should be considered before initiating tirzepatide in high-risk patients, including those over 65 years of age, individuals with pre-existing gastrointestinal disorders, patients on concurrent metformin or acid-suppressing medications, and those following restrictive diets
Glutamine also served a more significant role in TCA anaplerosis in the kidney and the liver, as noted by the significant increases of the fractional contribution of glutamine to TCA cycle intermediates (Fig 6F)

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