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All the biological mechanisms result in a neuroprotection increase and lead, as a consequence, to a reduction of migraine headaches frequency, migraine pain reduction, and alleviation of the aura symptoms (red arrow on the right side of the graph)

J., Soluble Protein Oligomers in Neurodegeneration: Lessons from the Alzheimer's Amyloid Beta-Peptide, Nat

This may be caused by hyperinsulinaemia during the onset of the disease

Quantification of phosphorylated Jak2 and tubulin expressions were performed by calculating the band density using 1D Digital Analysis Software (Kodak Digital ScienceTM, Eastman Kodak Company, Rochester, NY, USA)