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Alternative diagnoses and diagnostic categories include, but are not limited to: Neuromuscular disorders (such as myopathic EDS and Bethlem myopathy) Other heritable connective tissue disorders (such as other types of EDS, LoeysDietz syndrome, Marfan syndrome) Skeletal dysplasias (such as osteogenesis imperfecta) Classical EDS (cEDS) If a person meets the diagnostic criteria for cEDS, genetic testing should be done to confirm the diagnosis

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This activation is characterized by a predominance of T helper 2 (TH2) lymphocytes, innate lymphoid cells type 2 (ILC2) and eosinophils

Petrovic et al., 2021