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As a 2025 comprehensive review by Jzwiak and colleagues in Pharmaceuticals (Basel) documents, BPC-157 was isolated from human gastric juice and has been studied in preclinical models since the early 1990s by a research group at the University of Zagreb

ii) Utilizing the steric hindrance conferred by dimerization reduces protease access to the active site and significantly improving stability against proteases 49,50

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