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213 p62 and dipeptidyl peptidase 9 (DPP9) disrupt the interaction between KEAP1 and NRF2 by competitively binding to KEAP1 to maintain the NRF2 stability and promote the transcription of its downstream iron metabolism and antioxidant genes, resulting in ferroptosis-mediated sorafenib resistance

( A ) Top 17 shRNA screen hits (minus GSTT1 , n = 16) were analyzed for impact on overall survival in pancreatic cancer (KMPlot) based on mean expression of selected genes (N = 177 samples)

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