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It is the hope that future studies will able to identify genetic risk factors associated with the structuring CD to better understand the pathogenesis of the development of intestinal fibrosis in IBD

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Animal models that lack genes responsible for protecting the guts epithelium, such as Mdr1a/, Irgm1/, and Sod2/ transgenic mice, exhibit an increased presence of impaired mitochondria in intestinal cells and are more susceptible to experimentally induced colitis (56)

They are getting a different, less effective one