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Moreover, the study demonstrated that NOX4-mediated redox-sensitive activation of the calmodulin-dependent protein kinase II (CaMKII)/ERK1/2/myosin light chain kinase pathway plays a significant role in this process, as observed in a preclinical model of sepsis induced by cecal ligation puncture [81]

GHK-Cu is a naturally occurring peptide that binds with copper ions, making it commonly referred to as a copper peptide in research literature

These cells, often referred to as drug-tolerant persisters (DTPs) and analogous to bacterial persisters, survive temporarily under therapy but quickly regain sensitivity and proliferative capacity once the drug is removed 11

*Correspondence: Yamin Li [email protected] This article was submitted to Molecular Psychiatry, a section of the journal Frontiers in Psychiatry Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers