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In short, all these different studies demonstrate the relevance of optimizing the ligands of E3 ligases, in this specific case of cereblon E3 ligase, for their incorporation into the construction of more potent, selective, stable PROTACs with the desirable pharmacokinetic properties for oral administration

They are not for human consumption, clinical use, or any diagnostic, cosmetic or veterinary application

Tirzepatide (Mounjaro, Zepbound) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management (Mounjaro) and chronic weight management (Zepbound)

Schuldiner M, Zalckvar E (2017) Incredibly close-a newly identified peroxisome-ER contact site in humans