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For body recomposition, the combination of a GH secretagogue with AOD 9604, a fragment of human growth hormone that drives lipolysis through beta-3 adrenergic receptors without affecting muscle anabolism, is worth considering for patients whose primary concern is concurrent fat loss and muscle preservation

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Additionally, the amenability of PLGA nanosystems to functionalization by ligands (lactoferrin) or polymers (PEG) could facilitate targeted delivery, ensuring efficient delivery of their cargos to target tissues and thus minimizing off-target effects 31

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