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Bal-Price and Brown demonstrated similar finding using astrocytes and microglia exposed to LPS or interferon- in which blocking nitric oxide (NO) production induced by the inflammatory cytokines, prevented neurotoxicity.[14] Further, they found that the NO rapidly inhibited mitochondrial respiration and this increased glutamate release from neuronal/astrocytic cultures

Role of Glutathione in Aging Although higher GSH concentrations have been associated with good health, the significance of low GSH status in the elderly is inferred from limited data

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The IRS-signalling system: a network of docking proteins that mediate insulin action