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Drug screening was performed as previously described ( Determination of yeast cytosolic pH was performed as previously described ( ADH plasmid containing a pH-sensitive ratiometric GFP variant named pHluorin (kindly obtained from S

Isopsoralen alleviated joint bone erosion and inhibited RANKL-induced osteoclast formation by blocking the NF-B signaling pathway ( Artemisia dracunculus significantly increased osteogenic gene expression and increased mineralization ( In general, bioactive components of TCM can inhibit the proliferation and migration of fibroblast synovial cells, reduce osteoclast differentiation, bone resorption and cartilage degradation, and resolve the inflammation of RA

Administration of pioglitazone reduced levels of IL-6, TNF- and increased levels of IL-10 [76]

Tumor cells and inflamed cells have high ROS levels, causing high GSH levels to maintain redox homeostasis