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High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)

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While opioids activate brain chemistry related to pleasure and dependence by binding to mu-opioid receptors, acetaminophen primarily reduces pain by blocking cyclooxygenase (COX) enzymes in the brain and spinal cord
