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Beyond this remodeling effect, berberine hydrochloride down-regulates the efflux-pump gene CDR1 , reducing fluconazole extrusion and further sensitizing resistant strains (Zhu et al., 2014)

This analysis revealed the presence of several known stress-related cis -acting elements such as abscisic acid responsive element (ABRE), anaerobic response element (ARE), fungal elicitor responsive element (BOX-W1), MYBHv1 binding site (CCAAT box), Methyl jasmonate-responsive element (CGTCA box and TGACG motif), heat shock element (HSE), low temperature responsive (LTR), MYB-binding site (MBS), gibberellin-responsive element (TATC-box), defence and stress response (TC-rich repeats), salicylic acid response element (TCA element), auxin responsive element (TGA element), W box, wound responsive element (WUN-motif) and transcription inducer (5-UTR Py-rich stretch) (Fig