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We ask our patients to refrain from rubbing the area or exercising for 90 minutes after, and the use of ice on the area should be avoided

Presystemic elimination of budesonide in man when administered locally at different levels in the gut, with and without local inhibition by ketoconazole

"It does provide reassurance that delays for whatever reason, be it the weather or problems in the supply chain it provides some comfort knowing that those individuals who have received the one dose do achieve a good level of protection," he said