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Although the results from the other four methods (Simple mode, Weighted mode, MR Egger, and Weighted median) did not reach statistical significance, the odds ratios were consistently in the same direction as the IVW findings (Simple mode: OR = 1.046, P = 0.560

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Most practitioners recommend starting at 250-300 mcg daily to assess tolerance, then potentially increasing to 400-500 mcg if initial response is suboptimal and no side effects occur

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