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Office of Dietary Supplements Vitamin B6. NIH Office of Dietary Supplements, U.S
Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes

First, growth hormones fat-mobilizing effect is coupled, in the intact hormone, to metabolically costly side effects: the same signaling that liberates fatty acids also raises circulating IGF-1 and can worsen insulin sensitivity, which is precisely why chronic growth-hormone administration is not a benign way to lose fat

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