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Hayes, S

Other supportive evidence is the correlation of the rate of transport of a given substance with transcellular electrical resistance, in which lower transport rates of substances assumed to be transported paracellularly are observed in high-resistance, tight epithelia, although electrical resistance and the transport of marker molecules do not always coincide

but if used improperly (for example, if accidentally infused alone), it can cause serious complications like hemolysis

Of the 60 patients who completed the study, those who used methylene blue oral rinse reported significantly reduced pain after two days of treatment