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Status of clinical trials involving anti-IGFs and IGF-1R mAbs The preclinical findings that support IGF-1 and its receptor IGF-1R as potential therapeutic targets led to the initiation of many clinical trials in the last decade (Table 1)

doi: 10.1186/1471-2350-11-36

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In a mechanistic study with different types of tumour cell lines, the silencing of Grx1 activated the p53 signalling pathway, causing the cell cycle to stop in G1 causing senescence [188], which supported the idea that antioxidant systems, including Grx1, get upregulated in tumour cells as survival mechanism to counteract the high amount of ROS due to the changes in metabolism