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For example, human induced pluripotent stem cell (iPS cell) astrocyte studies indicate that PSEN1 mutations enhance cytokine signaling via disrupted intramembrane proteolysis, lowering the threshold for astrocyte reactivity and predisposing cells to exaggerated inflammatory responses to modest stimuli 79
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Enantiomers of naringenin as pleiotropic, stereoselective inhibitors of cytochrome P450 isoforms
The assessment of myocardial strain may also help to early detect cardiotoxicity in cancer patients (58), Ye et al
