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Refrigeration isn't just "better" - it can extend usable life by 3-10x depending on the form

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society , 60 Suppl 7 , 115122
Age-dependent regulation of GABA transmission by kappa opioid receptors in the basolateral amygdala of Sprague-Dawley rats

In some cases, a hysteroscopy may also be indicated to closely evaluate the endometrium for inflammation
