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Tanzania ENT Society 2017 Congress

In a mouse model of hepatocellular carcinoma, regulatory T cells (Tregs) with high IGF-1R expression presented increased PI3K/AKT/mTOR signaling and were able to produce more ATP, lactate and ROS, which contribute to enhanced immunosuppressive effects (72)

For patients, it highlights a practical message: a "normal" lab result may not always tell the full story, particularly when subtle changes in memory, thinking speed, or vision are already appearing

Begley J, Ribas A
