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Using site-directed mutagenesis, the authors showed that the Cys50Cys89 disulfide bridge was not essential for antimicrobial activity (Ge et al., 2003)

Due to its unique biochemical function of directly reducing lipid peroxides and blocking the oxidative chain reaction on cell membranes, GPX4 is often regarded as the central barrier or gatekeeping enzyme in the ferroptosis response

One proposed intracellular pathway involves the enzyme adenylyl cyclase, which is hypothesized to convert adenosine triphosphate (ATP) into cyclic adenosine monophosphate (cAMP)

Circulating endocannabinoids: from whence do they come and where are they going