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It was first described in the rat BBB at the luminal membrane and it was pH sensitive and moderately tolerant of Li + substitution for Na + (Ruderisch et al., 2011), while transcripts of SNAT5 (SLC38A5) have also been detected in mouse BBB ( Transport of Acidic AAs: EAATs Transporters Acidic amino acids Glu and Asp are transported from brain to blood
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These cells secrete inhibitory cytokines such as TGF- and IL-10, and express immune checkpoint molecules such as PD-L1, jointly weakening the effector functions of cytotoxic CTLs and natural killer cells, thereby promoting tumor immune escape [88]
