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It resulted in increased activity in the dorsal horn activity and the development of mechanical allodynia in those rats, when an equivalent concentration of oxaliplatin was directly applied to the spinal dorsal surface

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TNF-, IL-1 and IL-6 are associated with activation of bone-resorbing processes, and IL-8 is reported to polymorphonuclear leukocyte activity.[5,34] More recently, Dias et al .,[99] first time revealed that significant redox disturbances exist in neutrophils of patients with periodontitis, which are associated with deregulation of anti-inflammatory transcription factor Nrf2 pathway resulting in neutrophil hyperactivity/hyper-reactivity

Hansson, L