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Insulin receptor substrate-1 (IRS1) and Shc compete for a limited pool of Grb2 in mediating insulin downstream signaling
10), indicating reduced metabolic flexibility with age
A 28-day administration of BPC 157 (4, 1, or 0.2 mg/kg/day, i.m.) in rats and (2, 0.5, or 0.1 mg/kg/day) in beagle dogs also resulted in no apparent changes as compared to saline-treated animals
