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Although there is no unified hypothesis, it is certain that the factors impacting AD onset are manifold: they can range from diet to metabolic diseases (such as diabetes and CVD) (3), infections (4), brain injuries (5) to toxicity from metals and PM 2.5 (5, 6) and many others

P2X7R-mediated autophagic impairment contributes to central sensitization in a chronic migraine model with recurrent nitroglycerin stimulation in mice

After incubating samples for 20 min on ice and centrifuging at 14,000 g for 15 min at 4C, we transferred the supernatants to new microfuge tubes for subsequent evaporation using a vacuum evaporator at room temperature

Note: This food supplement should not be used to replace a balanced and varied diet and a healthy way of life