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Description
Similar to the TCA cycle, OXPHOS is not only involved in catabolism for energy production, but also plays an essential role in anabolism, where the synthesis of some amino acids depends on OXPHOS activity as a key to cell proliferation
Protocol: Dosing typically follows a titration schedule , starting at a low dose (e.g., 0.3 mg) and gradually escalating every four weeks until the target dose (2.4 mg) is achieved
A: Injectable: $30-60 per month
This may explain a crucial role for activating Met mutations, although their frequency in primary tumors seems to be very low (29)
