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The therapeutic effects of these compounds in animal models and in vitro studies either in delaying motor symptoms, protecting against motor neuron loss and/or improving survival suggest that further studies should be performed to characterize abnormalities in energy metabolism in ALS and explore potential metabolic therapies

If your clinician agrees to a trial, start with a low dose and recheck labs in four to eight weeks

Cell Death Differ 28(7):2045-59 2021 PMC8257617 Hu Q, Wu D, Walker M, Wang P, Tian R, Wang W

The androgen-specific probasin response element 2 interacts differentially with androgen and glucocorticoid receptors