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Necroptosis is a programmed necrosis triggered by cytokines such as tumor necrosis factor (TNF) and relies on receptor-interacting protein kinase 1 (RIPK1), RIPK3, and mixed lineage kinase domain-like protein (MLKL)

These events were reported early during therapy, and tended to be transient and/or responsive to dosage reduction

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This may suggest that either the two GSTs have fundamentally different binding affinities for the liganamide conjugates, or that during extraction, At GSTF2 was transiently in closer proximity to the generation of these artifacts than At GSTU19